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This video shows the multi-physics simulation results of opening-filling-closing process of a flexible pouch using RecurDyn. Coesia S.p.A., which is a leading multi-national packaging company headquartered in Italy, partnered with both EnginSoft S.p.A. and the University of Trento to simulate the full process through which a stand-up pouch is created, filled with liquid, and sealed in a Doypack® packaging machine. This challenging activity required the development of a multi-physics digital prototype of the machine-package-fluid system. In particular, the two-way coupling between multi flexible body dynamics and particle-based fluid dynamics was set up to properly replicate the interactions between fluid and a flexible pouch in dynamic conditions.